A novel PSMA-targeting tracer with highly negatively charged linker demonstrates decreased salivary gland uptake in mice compared to [ 68 Ga]Ga-PSMA-11.

Steve S HuangFrank P DiFilippoDaniel J LindnerWarren D Heston

Published in: EJNMMI radiopharmacy and chemistry (2024)

Ga]Ga-PSMA-11. Our findings suggest that constructing a PSMA-targeting molecule with a highly negatively charged linker is a promising strategy to reduce salivary gland uptake of GCP-II/PSMA ligands in theranostic applications.

Keyphrases

pet ct
positron emission tomography
photodynamic therapy
pet imaging
computed tomography
metabolic syndrome
adipose tissue
fluorescence imaging