Antioxidants as Therapeutic Agents in Acute Respiratory Distress Syndrome (ARDS) Treatment-From Mice to Men.
Andreas von KnethenUlrike HeinickeVolker LauxMichael J ParnhamAndrea U SteinbickerKai ZacharowskiPublished in: Biomedicines (2022)
Acute respiratory distress syndrome (ARDS) is a major cause of patient mortality in intensive care units (ICUs) worldwide. Considering that no causative treatment but only symptomatic care is available, it is obvious that there is a high unmet medical need for a new therapeutic concept. One reason for a missing etiologic therapy strategy is the multifactorial origin of ARDS, which leads to a large heterogeneity of patients. This review summarizes the various kinds of ARDS onset with a special focus on the role of reactive oxygen species (ROS), which are generally linked to ARDS development and progression. Taking a closer look at the data which already have been established in mouse models, this review finally proposes the translation of these results on successful antioxidant use in a personalized approach to the ICU patient as a potential adjuvant to standard ARDS treatment.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- extracorporeal membrane oxygenation
- intensive care unit
- reactive oxygen species
- healthcare
- case report
- end stage renal disease
- chronic kidney disease
- oxidative stress
- palliative care
- newly diagnosed
- stem cells
- cardiovascular events
- type diabetes
- bone marrow
- dna damage
- combination therapy
- pain management
- risk assessment
- smoking cessation
- chemotherapy induced