Conducting polymer-based scaffolds for neuronal tissue engineering.
Hagje YiRajkumar PatelKapil D PatelLouis-S BouchardAmitabh JhaAdam Willis PerrimanMadhumita PatelPublished in: Journal of materials chemistry. B (2023)
Neuronal tissue engineering has immense potential for treating neurological disorders and facilitating nerve regeneration. Conducting polymers (CPs) have emerged as a promising class of materials owing to their unique electrical conductivity and biocompatibility. CPs, such as poly(3,4-ethylenedioxythiophene) (PEDOT), poly(3-hexylthiophene) (P3HT), polypyrrole (PPy), and polyaniline (PANi), have been extensively explored for their ability to provide electrical cues to neural cells. These polymers are widely used in various forms, including porous scaffolds, hydrogels, and nanofibers, and offer an ideal platform for promoting cell adhesion, differentiation, and axonal outgrowth. CP-based scaffolds can also serve as drug delivery systems, enabling localized and controlled release of neurotrophic factors and therapeutic agents to enhance neural regeneration and repair. CP-based scaffolds have demonstrated improved neural regeneration, both in vitro and in vivo , for treating spinal cord and peripheral nerve injuries. In this review, we discuss synthesis and scaffold processing methods for CPs and their applications in neuronal tissue regeneration. We focused on a detailed literature review of the central and peripheral nervous systems.
Keyphrases
- tissue engineering
- stem cells
- peripheral nerve
- spinal cord
- cell adhesion
- cerebral ischemia
- spinal cord injury
- wound healing
- cell cycle arrest
- case report
- mass spectrometry
- oxidative stress
- high throughput
- neuropathic pain
- signaling pathway
- reduced graphene oxide
- multidrug resistant
- cell death
- human health
- subarachnoid hemorrhage
- carbon nanotubes