Debamestrocel multimodal effects on biomarker pathways in amyotrophic lateral sclerosis are linked to clinical outcomes.
Stacy R LindborgNamita A GoyalJonathan KatzMatthew BurfordJenny LiHaggai KaspiNatalie AbramovBruno BoulangerJames D BerryKatharine NicholsonTahseen MozaffarRobert MillerLiberty JenkinsRobert H BalohRichard A LewisNathan P StaffMargaret Ayo OwegiBob DagherNetta R Blondheim-ShragaYael GothelfYossef S LevyRalph KernRevital ArichaAnthony J WindebankRobert BowserRobert H BrownMerit E CudkowiczPublished in: Muscle & nerve (2024)
Following debamestrocel treatment, many biomarkers showed increases (anti-inflammatory/neuroprotective) or decreases (inflammatory/neurodegenerative) suggesting a possible treatment effect. Neuroinflammatory and neuroprotective biomarkers were predictive of clinical response, suggesting a potential multimodal mechanism of action. These results offer preliminary insights that need to be confirmed.