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High glucose concentration produces a short-term increase in pERK1/2 and p85 proteins, having a direct angiogenetic effect by an action similar to VEGF.

Ferdinando Carlo SassoCandida ZuchegnaMario Felice TecceAnna CapassoLuigi Elio AdinolfiAntonella RomanoSilvia BartollinoAntonio PorcelliniCiro Costagliola
Published in: Acta diabetologica (2020)
Under these conditions, high glucose concentration and VEGF also produced a short-term increase in pERK1/2 and p85 proteins, while total and phosphorylated AKT were not affected. These data suggest a direct angiogenetic effect of glucose, affecting intracellular transduction mechanisms with an action similar to that of VEGF. This effect on endothelial cell proliferation and differentiation could be part of pathogenetic mechanisms producing diabetic microvascular alterations.
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