Predicting the dose of vancomycin in ICU patients receiving different types of RRT therapy: a model-based meta-analytic approach.
Guillaume ClaissePaul J ZuffereyJane C TroneNicolas MaillardXavier DelavenneSilvy LaporteEdouard OllierPublished in: British journal of clinical pharmacology (2019)
The PK model allowed accurate prediction of the vancomycin pharmacokinetics during RRT in ICU patients. Based on the model of RRT-induced clearance, an appropriate adjustment of the vancomycin dosing regimen could be proposed for any kind of flowrate settings.
Keyphrases
- methicillin resistant staphylococcus aureus
- intensive care unit
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- mechanical ventilation
- prognostic factors
- high resolution
- high glucose
- stem cells
- staphylococcus aureus
- diabetic rats
- mass spectrometry
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- patient reported