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Landscape of somatic alterations in large-scale solid tumors from an Asian population.

Liqun WuHe-Rui YaoHui ChenAodi WangKun GuoWenli GouYanfei YuXiang LiMing YaoShaohua YuanFei PangJinwei HuLijuan ChenWenjin LiuJicheng YaoShuirong ZhangXiaowei DongWeifeng WangJing HuQi LingSongming DingYan WeiQiang LiWeichun CaoShuang WangYang DiFeiling FengGang ZhaoJian ZhangLing HuangJia XuWangjun YanZhongsheng TongDa JiangTao JiQiao LiLing XuHui-Ying HeLiang ShangJin LiuKefeng WangDuoguang WuJing-Nan ShenYe LiuTing ZhangChaojie LiangYusheng WangYanhong ShangJianji GuoGuanbiao LiangShifeng XuJunfeng LiuKai WangMinghui Wang
Published in: Nature communications (2022)
Extending the benefits of tumor molecular profiling for all cancer patients requires a comprehensive analysis of tumor genomes across distinct patient populations worldwide. In this study, we perform deep next-generation DNA sequencing (NGS) from tumor tissues and matched blood specimens from over 10,000 patients in China by using a 450-gene comprehensive assay, developed and implemented under international clinical regulations. We perform a comprehensive comparison of somatically altered genes, the distribution of tumor mutational burden (TMB), gene fusion patterns, and the spectrum of various somatic alterations between Chinese and American patient populations. Here, we show 64% of cancers from Chinese patients in this study have clinically actionable genomic alterations, which may affect clinical decisions related to targeted therapy or immunotherapy. These findings describe the similarities and differences between tumors from Chinese and American patients, providing valuable information for personalized medicine.
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