Decreased Risk of Strokes in Children with Ventricular Assist Devices Within ACTION.
David M PengMuhammad F ShezadAngela LortsRobert J GajarskiChristina VanderPluymJenna M MurrayBeth HawkinsChet R VillaFarhan ZafarDavid N Rosenthalnull nullPublished in: Pediatric cardiology (2022)
We sought to characterize strokes in children with ventricular assist devices. Of 407 patients in the ACTION registry (4/1/18-5/3/2021), 45 (11%) experienced 52 strokes (45 ischemic and 7 hemorrhagic). Median time to stroke was 23.5 days and 19/52 (37%) occurred ≤ 10 days. Stroke rate was 0.09 and 0.63 strokes per patient-year for implantable continuous and paracorporeal devices, respectively. Patients with stroke were younger, more likely to have congenital heart disease and have been on extracorporeal membrane oxygenation at time of VAD. Based on these data, ACTION is now focused on decreasing strokes in these higher-risk patients with particular attention to the peri-implant period.
Keyphrases
- extracorporeal membrane oxygenation
- congenital heart disease
- atrial fibrillation
- end stage renal disease
- acute respiratory distress syndrome
- heart failure
- young adults
- catheter ablation
- left ventricular
- ejection fraction
- cerebral ischemia
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- electronic health record
- machine learning
- big data
- oxidative stress
- blood brain barrier
- subarachnoid hemorrhage