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Sulforaphane activates CD8 + T cells antitumor response through IL-12RB2/MMP3/FasL-induced MDSCs apoptosis'.

Jinyan LiuHuanan ChenCaijuan GuoJieyao LiMiaomiao LiMing ZhaoZiyi FuZhen ZhangFeng LiXuan ZhaoLi YangLiping WangQuanjun LvYi Zhang
Published in: Journal for immunotherapy of cancer (2024)
T cells through IL-12RB2/MMP3/FasL induced apoptosis, thus providing a strategy for targeting MDSCs to control tumors and improve clinical efficacy.
Keyphrases
  • induced apoptosis
  • endoplasmic reticulum stress
  • oxidative stress
  • diabetic rats
  • signaling pathway
  • cell migration
  • high glucose
  • cancer therapy
  • cell cycle arrest
  • drug delivery
  • cell proliferation
  • stress induced