Cdon ablation in motor neurons causes age-related motor neuron degeneration and impaired sciatic nerve repair.
Sunghee KimSubin AnJinwoo LeeYideul JeongChang-Lim YouHyebeen KimJu-Hyeon BaeChae-Eun YunDongryul RyuGyu-Un BaeJong-Sun KangPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Our current data demonstrate the functional importance of Cdon in motor neuron function and nerve repair. Cdon ablation causes alterations in neurotrophin signalling that leads to motor neuron degeneration.