Ultrasensitive DNA hypermethylation detection using plasma for early detection of NSCLC: a study in Chinese patients with very small nodules.
Chen ChenXiaojie HuangWei YinMuyun PengFang WuXia WuJingqun TangMingjiu ChenXiang WangAlicia HulbertMalcolm V BrockWenliang LiuJames G HermanFenglei YuPublished in: Clinical epigenetics (2020)
Using modified MOB-qMSP, high sensitivity and specificity, for the detection of circulating tumor DNA was obtained for early stage NSCLC. This strategy has great potential to identify patients at high risk and improve the diagnosis of lung cancer at an earlier stage.
Keyphrases
- circulating tumor
- cell free
- early stage
- small cell lung cancer
- circulating tumor cells
- end stage renal disease
- label free
- ejection fraction
- newly diagnosed
- chronic kidney disease
- advanced non small cell lung cancer
- loop mediated isothermal amplification
- single molecule
- gold nanoparticles
- peritoneal dialysis
- prognostic factors
- quantum dots
- climate change
- brain metastases
- nucleic acid
- neoadjuvant chemotherapy
- patient reported