ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis.
Liuyi HaoWei ZhongHaibo DongWei GuoXinguo SunWenliang ZhangRuichao YueTianjiao LiAlexandra GriffithsAli Reza AhmadiZhaoli SunZhenyuan SongZhanxiang ZhouPublished in: Gut (2020)
This study demonstrates that hepatic ATF4 plays a pathological role in alcohol-induced mitochondrial dysfunction and liver injury by disrupting the NRF1-TFAM pathway.