Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice.
Soracha E WardThomas GuestCiara M ByrnePatricia LopesJamie M O'SullivanDearbhla DohertyDavid O'ConnellSara Gutierrez LlanezaAlain ChionJudicael FazavanaPadraic G FallonRoger J S PrestonJill M JohnsenSteven W PipePeter L TurecekJames S O'Donnellnull nullPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
Cumulatively, these findings demonstrate that MGL plays an important role in regulating macrophage-mediated clearance of both VWF-bound FVIII and free-FVIII in vivo. We propose that this novel FVIII clearance pathway may be of particular clinical importance in patients with type 2N or type 3 Von Willebrand disease.