Genetic characteristics of HIV-1 CRF06_cpx and CRF56_cpx strains isolated in Guangzhou, China.
Yun LanLinghua LiWeiping CaiJunbin LiXizi DengFeng LiChunliang LeiFengyu HuXiaoping TangPublished in: Archives of virology (2021)
Strains of the HIV-1 circulating recombinant forms (CRFs) 06_cpx and 56_cpx were identified for the first time in Guangzhou, China. The nearly full-length genome (NFLG) sequence was amplified, and the PCR products were sequenced by the Sanger method. The CRF06_cpx and CRF56_cpx strains were identified using the Basic Local Alignment Search Tool (BLAST) and confirmed by neighbour-joining (NJ) phylogenetic analysis. Additionally, these strains were found to contain transmitted drug resistance mutations that have little effect on first-line efavirenz (EFV)-based treatment. Genetic analysis of the detailed sequence data will provide more information on the HIV-1 epidemic in China.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- hiv testing
- human immunodeficiency virus
- hepatitis c virus
- hiv aids
- escherichia coli
- men who have sex with men
- genome wide
- hiv infected patients
- electronic health record
- south africa
- copy number
- oxidative stress
- healthcare
- cell free
- smoking cessation
- replacement therapy