HLA-DQ2 is associated with anti-drug antibody formation to infliximab in patients with immune-mediated inflammatory diseases.

Marthe Kirkesaether Brun Kristin Hammersbøen Bjørlykke Marte K Viken Grethe-Elisabeth Stenvik Rolf Anton Klaasen Johanna Elin GehinDavid John WarrenJoseph SextonØystein SandangerTore K KvienCato MørkEspen A HaavardsholmJørgen JahnsenGuro Løvik Goll Benedicte A LieNils BolstadKristin Kaasen Jørgensen Silje Watterdal Syversen

Published in: Journal of internal medicine (2023)

A genome-wide significant association between two HLA-DQ2 haplotypes and the risk of ADAb formation to infliximab was identified, suggesting that HLA-DQ2 testing may facilitate personalised treatment decisions.

Keyphrases

genome wide
celiac disease
ulcerative colitis
dna methylation
emergency department
drug induced
adverse drug
replacement therapy
electronic health record