Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins.

Galen C Rask Cenny Taslim Ariunaa Bayanjargal Matthew V CannonJulia Selich-AndersonJesse C CrowAundrietta DuncanEmily Rose Theisen

Published in: bioRxiv : the preprint server for biology (2024)

activity against multiple FET fusion proteins that cause a number of rare and aggressive sarcomas. These data represent one of the largest analyses of FET fusion activity across multiple malignancies and are a valuable resource for those studying FET-rearranged sarcomas.

Keyphrases

high grade
gene expression
transcription factor
big data
heat stress