Biomarkers of bleeding and venous thromboembolism in patients with acute leukemia.

Yohei HisadaSierra J ArchibaldKaran BansalYanjun ChenChen DaiSindhu DwarampudiNora BalasLindsey HagemanNigel S KeySmita BhatiaRavi BhatiaNigel MackmanRadhika Gangaraju

Published in: medRxiv : the preprint server for health sciences (2023)

The mechanisms of acute leukemia-associated bleeding and thrombosis have not been elucidated.We measured plasma biomarkers of coagulation and fibrinolysis in acute leukemia patients.Biomarkers of the coagulation and fibrinolytic pathways are altered in acute leukemia patients.EVTF activity is associated with bleeding, and PAI-1 is associated with VTE in acute leukemia.

Keyphrases

venous thromboembolism
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
atrial fibrillation
prognostic factors
direct oral anticoagulants
patient reported