Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.
Gizem KeceliAshish GuptaJoevin SourdonRefaat E GabrMichael SchärSwati DeyCarlo Gabriele TocchettiAnnina StuberJacopo AgrimiYi ZhangMichelle LeppoCharles SteenbergenShenghan LaiLisa R YanekBrian O'RourkeGary GerstenblithPaul A BottomleyYibin WangNazareno PaolocciRobert G WeissPublished in: Circulation research (2022)
In the failing human heart, pathologic hypertrophy and adverse remodeling are closely related to deficits in ATP levels and in the CK energy reserve reaction. CKmito, sitting at the intersection of cardiac energetics and redox balance, plays a crucial role in attenuating pathologic remodeling in HF. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT00181259.
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