Cell-Free DNA Maps Tissue Injury and Correlates with Disease Severity in Lung Transplant Candidates.
Shanti BalasubramanianMary E RichertHyesik KongSheng FuMoon Kyoo JangTemesgen E AndargieMichael B KellerMuhtadi AlnababtehWoojin ParkZainab ApalaraJian SunNeelam RedekarJonathan OrensShambhu AryalErrol L BushEdward CantuJoshua M DiamondPali ShahKai YuSteven D NathanSean Agbor-EnohPublished in: American journal of respiratory and critical care medicine (2023)
Lung transplant candidates demonstrate a heightened degree of tissue injury with elevated cell-free DNA, primarily originating from innate immune cells. Pre-transplant plasma cell-free DNA levels predict post-transplant complications.
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