Insulin within the Arcuate Nucleus Has Paradoxical Effects on Nociception in Healthy and Diabetic Rats.
Hossein Khaleghzadeh-AhangarForouzan SadeghimahalliShaghayegh KhandanSima ShahabiAli Akbar MoghadamniaPublished in: Basic and clinical neuroscience (2020)
Intra-arcuate insulin has paradoxical and controversial effects in healthy and diabetic rats' nociception. These effects seem to be due to the insulin effect on releasing proopiomelanocortin and its derivatives.