Plasma Tryptophan-Kynurenine Pathway Metabolites and Risk for Progression to End-Stage Kidney Disease in Patients With Type 2 Diabetes.
Jian-Jun LiuJianhong ChingHai Ning WeeSylvia LiuResham L GurungJanus LeeYiamunaa MHuili ZhengLye Siang LeeKeven AngYi Ming ShaoJean-Paul KovalikTavintharan SubramaniamChee Fang SumKumar SharmaBryan R KestenbaumJian-Jun LiuPublished in: Diabetes care (2023)
Accelerated catabolism of tryptophan in the kynurenine pathway may be involved in progressive loss of kidney function. However, shunting the kynurenine pathway toward the kynurenic acid branch may potentially slow renal progression.
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