Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients.

Morena ScoteceAnna Koskinen-KolasaAntti PemmariTiina LeppänenMari HämäläinenTeemu MoilanenEeva MoilanenKatriina Vuolteenaho

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2020)

We show here, for the first time, that RBP4 is produced within OA joints and that it is associated with increased levels of adipokines and MMPs. The results suggest a role for RBP4 in the pathogenesis of OA and as a possible target for the disease-modifying drugs for the treatment of OA.

Keyphrases

knee osteoarthritis
end stage renal disease
binding protein
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes
combination therapy