Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer's disease model.

Xiaolei WuQi ShenZhan ZhangDi ZhangYing GuDa Xing

Published in: Stem cell research & therapy (2021)

Our study demonstrates that PBMT, as a viable therapeutic strategy, directs the adult hippocampal APP/PS1 NSCs differentiate towards neurons, which has great potential value for ameliorating the drop of AHN in Alzheimer's disease mice.

Keyphrases

signaling pathway
transforming growth factor
cerebral ischemia
epithelial mesenchymal transition
cognitive decline
spinal cord
pi k akt
mouse model
spinal cord injury
oxidative stress
high fat diet induced
induced apoptosis
blood brain barrier
young adults