β-cells in youth with impaired glucose tolerance or early type 2 diabetes secrete more insulin and are more responsive than in adults.
Kristina M UtzschneiderMark T TripputiAlexandra KozedubKieren J MatherKristen J NadeauSharon L EdelsteinTamara S HannonSilva A ArslanianMelanie Cree GreenThomas A BuchananSonia CaprioAndrea Marinull nullPublished in: Pediatric diabetes (2020)
Model-derived measures of β-cell function provide additional insight into the pathophysiology of type 2 diabetes in youth with higher ISRs and β-cell secretion more responsive to glucose in youth relative to adults even after adjusting for differences in insulin sensitivity. It is unknown whether these findings in youth reflect β-cells that are healthier or whether this is a defect that contributes to more rapid loss of function.
Keyphrases
- type diabetes
- induced apoptosis
- mental health
- physical activity
- young adults
- cell cycle arrest
- cancer therapy
- glycemic control
- endoplasmic reticulum stress
- cardiovascular disease
- blood glucose
- cell therapy
- oxidative stress
- metabolic syndrome
- insulin resistance
- blood pressure
- cell proliferation
- mesenchymal stem cells