Absence of Atg7 in the liver disturbed hepatic regeneration after liver injury.
Dorothee RömermannNadiea AnsariAdriana Rita Schultz-MoreiraAlina MichaelSilke MarhenkeMatthias Hardtke-WolenskiThomas LongerichMichael P MannsHeiner WedemeyerArndt VogelLaura Elisa Buitrago-MolinaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
We demonstrated the important role of autophagy in the regeneration capacity of hepatocytes. We showed the causative relationship between autophagy and triglycerides that is essential for promoting liver recovery. Finally, pharmacological mTOR inhibition overcame the impact of autophagy deficiency after liver damage and prevented mortality.