Integration of DNA sequencing with population pharmacokinetics to improve the prediction of irinotecan exposure in cancer patients.

Spinel KarasAmy S EtheridgeDeborah A NickersonNancy J CoxKaren L MohlkeErika CecchinGiuseppe ToffoliRon H J MathijssenAlan ForrestRobert R BiesFederico Innocenti

Published in: British journal of cancer (2021)

This new model significantly reduced the interindividual variability in the clearance of irinotecan and SN-38. New genetic factors of variability in clearance have been identified.

Keyphrases

circulating tumor
single molecule
genome wide
single cell
gene expression