Connectome-Based Propagation Model in Amyotrophic Lateral Sclerosis.
Jil M MeierHannelore K van der BurghAbram D NitertPeter BedeSiemon C de LangeOrla HardimanLeonard H van den BergMartijn P van den HeuvelPublished in: Annals of neurology (2020)
Our results are in accordance with established pathological staging systems and may have implications for patient stratification in future clinical trials. Our results demonstrate the utility of computational models in ALS to predict disease progression and underscore their potential as a prognostic biomarker. ANN NEUROL 2020;87:725-738.