Assessment of CFH and HTRA1 polymorphisms in age-related macular degeneration using classic and machine-learning approaches.
Antonieta Martínez-VelascoAndric C Perez-OrtizBani Antonio-AguirreLourdes Martínez-VillaseñorEsmeralda Lira-RomeroClaudia Palacio PastranaJuan Carlos Zenteno RuizIsrael RamirezClaudia Zepeda-PalacioCristina Mendoza-VelásquezAzyadeh Camacho-OrdóñezDaniela Michelle Ortiz BibriescaFrancisco J Estrada-MenaPublished in: Ophthalmic genetics (2020)
In sum, this work supports a strong association between HTRA1 genetic variants and AMD in Hispanics from Mexico, especially with GA. Moreover, ML was able to replicate the results of conventional biostatistics methods unbiasedly.