A simple method for the preparation of CeO 2 with high antioxidant activity and wide application range.

Cerium oxide (CeO 2 ) is a well-known antioxidant with the ability to scavenge reactive oxygen species due to its unique electronic structure and chemical properties. Although many methods to enhance the antioxidant activity of CeO 2 have been reported, its antioxidant activity is still not high enough, and some enhancement effects are limited by the material concentration. There are also some CeO 2 obtained with high antioxidant activity at high concentrations, which is not conducive to the application of biomedicine. Therefore, it is urgent to obtain CeO 2 material with low cell cytotoxicity, high antioxidant activity and wide application range. In this work, rod-like metal organic framework derived CeO 2 (CeO 2 -MOF) was prepared by a simple method. Compared with the CeO 2 nanorods prepared by hydrothermal method, it shows better antioxidant activity compared with the CeO 2 nanorods prepared by hydrothermal method. Moreover, the advantage of CeO 2 -MOF's antioxidant activity is not affected by the hydroxyl radical and material concentrations The reason why CeO 2 -MOF has higher antioxidant activity should be attributed to its higher Ce 3+ content and larger specific surface area. In addition, CeO 2 -MOF also exhibits low cytotoxicity to HeLa cells and PC12 cells in vitro . The strategy of using MOF as a structural and compositional material to create CeO 2 provides a new method to explore highly efficient and biocompatible CeO 2 for practical applications.