7,8-Dihydroxiflavone Protects Adult Rat Axotomized Retinal Ganglion Cells through MAPK/ERK and PI3K/AKT Activation.

Caridad Galindo-Romero Beatriz Vidal VillegasJavier Asís-MartínezFernando Lucas-Ruiz Alejandro Gallego-Ortega Manuel Vidal-Sanz

Published in: International journal of molecular sciences (2021)

Phosphorylation and increased levels of AKT and MAPK through MCs and RGCs in retinas after DHF-treatment may be responsible for the increased and long-lasting RGC protection afforded by DHF after IONT.

Keyphrases

pi k akt
signaling pathway
cell cycle arrest
induced apoptosis
cell proliferation
oxidative stress
combination therapy
protein kinase
endoplasmic reticulum stress