A cis-eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma.

Lijuan MengYan ZhouSihan JuJing HanCi SongJing KongYifei WuShuai LuJiani XuWenwen YuanErbao ZhangCheng WangZhi-Bin Hu Yayun GuRongcheng LuoXue-Hao Wang

Published in: Cancer medicine (2019)

Taken together, our study demonstrated that PLK4 is a susceptibility gene and plays an oncogenic role in HCC. Furthermore, we identified that PLK4 sensitives HCC to CFI-400945, which may be an ideal therapy target for HCC.

Keyphrases

genome wide
copy number
dna methylation
bone marrow
cell therapy
smoking cessation