Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury.
Shining XiaoYu ZhangZihao LiuAnan LiWeilai TongXu XiongJiangbo NieNanshan ZhongGuoqing ZhuJiaming LiuZhili LiuPublished in: CNS neuroscience & therapeutics (2023)
Alpinetin can be used to treat neurodegenerative diseases and is a novel drug candidate for the treatment of microglia-mediated neuroinflammation.
Keyphrases
- spinal cord injury
- signaling pathway
- cerebral ischemia
- lipopolysaccharide induced
- traumatic brain injury
- lps induced
- inflammatory response
- neuropathic pain
- oxidative stress
- cognitive impairment
- endoplasmic reticulum stress
- spinal cord
- epithelial mesenchymal transition
- cell death
- cell cycle arrest
- cancer therapy
- induced apoptosis
- emergency department
- drug delivery
- brain injury
- replacement therapy
- drug induced
- smoking cessation