The effect of pirfenidone on rat chronic prostatitis/chronic pelvic pain syndrome and its mechanisms.
Xufeng PengHailin GuoJun ChenJihong WangJianwen HuangPublished in: The Prostate (2020)
Pirfenidone can exert a beneficial effect against CFA-induced CP/CPPS by anti-inflammatory, antioxidative, antifibrotic properties, and the function is mediated at least partly through the M2 polarization of macrophages and the inhibition of NF-κB signaling pathway. These findings suggest that pirfenidone holds promise as a potential therapeutic for the treatment of CP/CPPS.
Keyphrases
- idiopathic pulmonary fibrosis
- pulmonary fibrosis
- signaling pathway
- anti inflammatory
- pi k akt
- oxidative stress
- drug induced
- epithelial mesenchymal transition
- high glucose
- induced apoptosis
- lps induced
- rectal cancer
- nuclear factor
- big data
- immune response
- cell proliferation
- toll like receptor
- endoplasmic reticulum stress