Relative effects of LDL-C on ischemic stroke and coronary disease: A Mendelian randomization study.
Elsa Valdes-MarquezSarah ParishRobert ClarkeTraiani StariBradford B Worrallnull nullJemma C HopewellPublished in: Neurology (2019)
In contrast with the consistent effects of LDL-C-lowering therapies on IS and CHD, genetic variants that confer lifelong LDL-C differences show a weaker effect on IS than on CHD. The relevance of etiologically distinct IS subtypes may contribute to the differences observed.