Lithium attenuates blood-brain barrier damage and brain edema following intracerebral hemorrhage via an endothelial Wnt/β-catenin signaling-dependent mechanism in mice.
Dengpan SongYa-Bin JiXiao-Wen HuangYin-Zhong MaCheng FangLin-Hui QiuXi-Xi TanYi-Man ChenSheng-Nan WangJunlei ChangFuyou GuoPublished in: CNS neuroscience & therapeutics (2022)
Our findings indicate that lithium may serve as a therapeutic candidate for treating BBB breakdown and brain edema following ICH.