Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.
Tanya TranMichael J SpilkaIan M RaughGregory P StraussCarrie E BeardenKristin S CadenheadTyrone D CannonBarbara A CornblattMatcheri KeshavanDaniel H MathalonThomas H McGlashanDiana O PerkinsLarry J SeidmanWilliam S StoneMing T TsuangElaine F WalkerScott W WoodsJean M AddingtonPublished in: Schizophrenia bulletin open (2023)
Continuous, frequent monitoring of negative symptoms in CHR is justified by 2 important study implications: (1) The initial 6 months of CHR program enrollment may be a key window for improving negative symptoms as less improvement is likely afterwards, (2) Early identification of clinical subgroups may inform distinct negative symptom trajectories and treatment needs.