Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter.

Caroline A CobineKaren I HanniganMegan McMahonEmer P Ni BhraonainSalah A BakerKathleen D Keef

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

The similarities in spatiotemporal and pharmacological properties of CTs and SWs suggest that SW gives rise to CTs while muscle stretch is not required. Elevated relative basal Ca2+ in the IAS is likely due to the inability of cells to clear or sequester Ca2+ between rapid frequency voltage-dependent Ca2+ entry events, that is, conditions that will lead to tone development. The conduction of CTs from distal to proximal IAS will lead to orally directed contractions and likely contribute to the maintenance of fecal continence.

Keyphrases

induced apoptosis
protein kinase
skeletal muscle
cell cycle arrest
minimally invasive
high grade
robot assisted
cell death
cell proliferation