Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study.
Åse Bjorvatn SævikGrethe Åstrøm UelandAnna-Karin ÅkermanPaal MethlieMarcus QuinklerAnders Palmstrøm JørgensenCharlotte HöybyeAleksandra W J DebowskaBjørn Gunnar NedrebøAnne Lise DahleSiri CarlsenAneta TomkowiczStina Therese SollidIngrid NermoenKaja GrønningPer DahlqvistGuri GrimnesJakob SkovTrine Elisabeth FinnesSusanna F VallandJeanette WahlbergSynnøve Emblem HolteOlle KämpeSophie BensingEystein Sverre HusebyeMarianne ØksnesPublished in: European journal of endocrinology (2023)
We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.