[PROINFLAMMATORY CYTOKINES AND SIGNALING PATHWAYS IN PERIPHERAL BLOOD MONONUCLEAR CELLS IN PATIENTS WITH CORONARY ARTERY DISEASE].

A V LogatkinaV S NikiforovS S BondarI V Terekhov

Published in: Klinicheskaia meditsina (2018)

Results of the study suggest persistent pro-inflammatory activation of whole blood cells in CHD patients due to enhanced levels of IL-1 and IL-2, components of the MAPK/SAPK signal pathway in MNC and decreased STAT3 level determining cell sensitivity to IL-10. The elevated intracellular level of ERK and JNK us responsible for high responsiveness of MNC to pro-inflammatory cytokines.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
end stage renal disease
cell cycle arrest
newly diagnosed
ejection fraction
chronic kidney disease
single cell
peritoneal dialysis
prognostic factors
endoplasmic reticulum stress
cell death
cell therapy
anti inflammatory
bone marrow