A novel program of infiltrative control in astrocytomas: ADAM23 depletion promotes cell invasion by activating γ -secretase complex.
Elisa Helena Farias JandreyGabriela Filoso BarnabéMarcos MaldaunPaula Fontes AsprinoNatália Cristina Dos SantosLilian Tiemi InoueAndrei RozanskiPedro Alexandre Favoretto GalanteSuely Kazue Nagahashi MarieSueli Mieko Oba-ShinjoTiago Góss Dos SantosRoger ChammasCarmen Lucia Penteado LancellottiFrank B FurnariAnamaria Aranha CamargoÉrico Tosoni CostaPublished in: Neuro-oncology advances (2023)
Our findings reveal a role for ADAM23 in regulating the balance between cell proliferation and invasiveness in astrocytoma cells, proposing GS inhibition as a therapeutic option in ADAM23 low-expressing astrocytomas.