Influence of Fc modifications and IgG subclass on biodistribution of humanized antibodies targeting L1CAM.

Sai Kiran SharmaMaya SuzukiHong XuJoshua A KorsenZachary SamuelsHongfen GuoBrandon NemiebokaAlessandra PiersigilliKimberly J EdwardsNai Kong V Cheung Jason S Lewis

Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2021)

Our findings highlight the influence of Fc-modifications and the choice of IgG subclass on the in vivo biodistribution of Abs and the potential outcomes thereof.

Keyphrases

pet imaging
cancer therapy
monoclonal antibody
human health
risk assessment