Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy.

Masataka Shimonosono Koji Tanaka Samuel Flashner Satoshi TakadaNorihiro MatsuuraYasuto TomitaUma M SachdevaEishi NoguchiVeena SangwanLorenzo FerriFatemeh Momen-HeraviAngela J YoonAndres J Klein-SzantoJ Alan DiehlHiroshi Nakagawa

Published in: Biomolecules (2021)

This study provides mechanistic insights into how EtOH may influence SCC cells and establishes autophagy as a potential therapeutic target for the treatment of EtOH-associated SCC.

Keyphrases

oxidative stress
induced apoptosis
endoplasmic reticulum stress
cancer stem cells
squamous cell carcinoma
cell death
signaling pathway
cell cycle arrest
dna damage
ischemia reperfusion injury
risk assessment
lymph node metastasis
climate change
human health
locally advanced
heat shock
heat stress