Long-term risk of major bleeding after discontinuing anticoagulation for unprovoked venous thromboembolism: a systematic review and meta-analysis.

Faizan KhanAlvi RahmanTobias TritschlerMarc CarrierClive KearonJeffrey I WeitzSam SchulmanFrancis CouturaudCecilia BecattiniGiancarlo AgnelliTimothy BrightonAnthonie Wa LensingLaurent PinedeSameer ParpiaG J GeersingToshihiko TakadaCharlotte BradburyGiuseppe Maria AndreozziGualtiero PalaretiPaolo PrandoniH R BullerRanjeeta MallickBrian HuttonKednapa ThavornGrégoire Le GalMarc RodgerDean A Fergusson

Published in: Thrombosis and haemostasis (2021)

Patients with a first unprovoked VTE have a non-trivial risk of major bleeding once anticoagulants are discontinued. Estimates from this study can help clinicians counsel patients about the incremental risk of major bleeding with extended anticoagulation to guide decision making about treatment duration for unprovoked VTE.

Keyphrases

venous thromboembolism
direct oral anticoagulants
atrial fibrillation
end stage renal disease
decision making
newly diagnosed
chronic kidney disease
ejection fraction
palliative care
peritoneal dialysis
prognostic factors
patient reported outcomes
patient reported