Minimal residual disease level predicts outcome in adults with Ph-negative B-precursor acute lymphoblastic leukemia.
Nicola GökbugetHervé DombretSebastian GiebelMonika BruggemannMichael DoubekRobin FoàDieter HoelzerChristopher KimGiovanni MartinelliElena N ParovichnikovaAlessandro RambaldiJosep-María RiberaMarieke SchoonenJulia M StieglmaierGerhard ZugmaierRenato BassanPublished in: Hematology (Amsterdam, Netherlands) (2019)
In conclusion, RFS, DoR, and OS are relatively short in patients with MRD-positive ALL, particularly at higher MRD levels. AlloHSCT may improve survival but has limitations. Alternative approaches are needed to improve outcomes in MRD-positive ALL.