Creation of single molecular conjugates of metal-organic cages and DNA.

Toshinobu Nakajo Shinpei Kusaka Haruka HiraokaKohei NomuraNoriaki MatsubaraRintaro BabaYuki YoshidaKosuke NakamotoMasakazu HonmaHiroaki Iguchi Takayuki Uchihashi Hiroshi Abe Ryotaro Matsuda

Published in: Chemical communications (Cambridge, England) (2023)

Here we report the development of an equimolar conjugate of a metal-organic cage (MOC) and DNA (MOC-DNA). Several MOC-DNA conjugates were assembled into a programmed structure by coordinating with a template DNA having a complementary base sequence. Moreover, conjugation with the MOC drastically enhanced the permeability of DNA through the lipid bilayer, presenting great potential as a drug delivery system.

Keyphrases

circulating tumor
single molecule
cell free
nucleic acid
mass spectrometry
drug delivery
risk assessment
high resolution
liquid chromatography