Targeting Endothelial ENO1 (Enolase) -PI3K-Akt-mTOR Axis Alleviates Hypoxic Pulmonary Hypertension.

Yuqing ShiJie LiuRuoyang ZhangMuzhi ZhangHan CuiLei WangYe CuiWei WangYing SunChen Wang

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

These results indicate that hypoxic pulmonary hypertension is associated with an increased level of ENO1 and that targeting ENO1 might reduce experimental hypoxic pulmonary hypertension by improving endothelial and mitochondrial dysfunction via PI3K-Akt-mTOR signaling pathway.

Keyphrases

pulmonary hypertension
pulmonary artery
pulmonary arterial hypertension
signaling pathway
endothelial cells
cancer therapy
pi k akt
mouse model
oxidative stress
cell proliferation
induced apoptosis
endoplasmic reticulum stress