Maternal obesity: sex-specific in utero changes in fetal brain autophagy and mTOR.
Nana MerabovaLierni UgartemendiaAndrea G EdlowClaudia IbarraNune DarbinianGabriel TatevosianLaura GoetzlPublished in: Obesity (Silver Spring, Md.) (2024)
We present novel evidence suggesting that in utero exposure to maternal obesity in humans may significantly affect neurodevelopment, especially in male fetuses, through alterations in normal autophagy molecular mechanisms and with adiponectin as a potential mediator.
Keyphrases
- insulin resistance
- metabolic syndrome
- birth weight
- weight gain
- weight loss
- cell death
- high fat diet induced
- endoplasmic reticulum stress
- type diabetes
- signaling pathway
- oxidative stress
- gestational age
- pregnancy outcomes
- adipose tissue
- skeletal muscle
- white matter
- resting state
- body mass index
- cerebral ischemia
- functional connectivity
- pregnant women
- risk assessment
- human health
- climate change
- preterm birth
- blood brain barrier