Impact of radiation technique, radiation fraction dose, and total cisplatin dose on hearing : Retrospective analysis of 29 medulloblastoma patients.

Sergiu ScobioalaRoss ParfittPeter MatulatChristopher KittelFatemeh EbrahimiHeidi WoltersAntoinette Am Zehnhoff-DinnesenHans Theodor Eich

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2017)

The cochlear radiation dose should be kept as low as possible in patients who receive simultaneous cisplatin-based chemotherapy. The risk of clinically relevant HL was shown when Dmean exceeds 45 Gy independent of radiation technique or radiation regime. Cisplatin ototoxicity was shown to have a dose-dependent effect on bilateral SNHL, which was more pronounced in higher frequencies.

Keyphrases

end stage renal disease
radiation induced
newly diagnosed
ejection fraction
chronic kidney disease
hearing loss
peritoneal dialysis
locally advanced