Granzyme B PET Imaging of Combined Chemotherapy and Immune Checkpoint Inhibitor Therapy in Colon Cancer.
Julian L GoggiSiddesh V HartimathTan Yun XuanShivashankar KhanapurBeverly JieuHui Xian ChinBoominathan RamasamyPeter ChengTang Jun RongYong Fui FongTsz Ying YuenRasha MsallamAnn-Marie ChackoLaurent ReniaCharles JohannesYou Yi HwangEdward G RobinsPublished in: Molecular imaging and biology (2021)
[18F]AlF-mNOTA-GZP tumor uptake, driven by changes in immune cell populations expressing GZB, is able to stratify tumor response to chemotherapeutics combined with ICIs. Our results show that, while the immunomodulatory mode of action of the chemotherapies may be different, the ultimate mechanism of tumor lysis through release of Granzyme B is an accurate biomarker for treatment response.