Atrial fibrosis heterogeneity is a risk for atrial fibrillation in pigs with ischaemic heart failure.

Zhihao ZhangJulia VlcekValerie PaulyNora HesseJulia BauerKavi Raj ChatautFlorian MaderspacherLina Sophie VolzKatharina BuchbergerRuibing XiaBianca HildebrandStefan KääbDominik SchüttlerPhilipp TomsitsSebastian Clauss

Published in: European journal of clinical investigation (2023)

Our results suggest that left atrial cross-regional fibrosis difference rather than overall fibrosis level is associated with IHF-related AF susceptibility, presumably by establishing local conduction disturbances and heterogeneity.

Keyphrases

atrial fibrillation
left atrial
catheter ablation
heart failure
oral anticoagulants
left ventricular
mitral valve
left atrial appendage
single cell
direct oral anticoagulants
percutaneous coronary intervention
liver fibrosis
drug induced
breast cancer risk